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Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cells

1 Sept 2010

Abstract excerpt

Unlike other retroviruses, human immunodeficiency virus type-1 (HIV-1) can infect terminally differentiated cells, due to the ability of its pre-integration complex (PIC) to translocate via the host nuclear pore complex (NPC). The PIC Nuclear import has been suggested to be mediated by the viral integrase protein (IN), via either the importin α or transportin 3 (TNPO3/transportin-SR2) pathways.We show that in...

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PMID: 21326825
DOI: 10.4161/nucl.1.5.12903

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Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cellsPMID 21326825Read ↗

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