Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear import.

Retrovirology - 18 Oct 2005

Ao Zhujun, Fowke Keith R, Cohen Eric A, Yao Xiaojian

Abstract excerpt

BACKGROUND: In addition to mediating the integration process, HIV-1 integrase (IN) has also been implicated in different steps during viral life cycle including reverse transcription and viral DNA nuclear import. Although the karyophilic property of HIV-1 IN has been well demonstrated using a variety of experimental approaches, the definition of domain(s) and/or motif(s) within the protein that mediate viral DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to HIV Integrase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luminescent Proteins

Share to Membrane Glycoproteins

Share to Protein Transport

Share to Viral Envelope Proteins

Share to Virus Integration

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 16232319
DOI: 10.1186/1742-4690-2-62
PMCID: PMC1277849

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear import.PMID 16232319Read ↗

Identification of critical amino acid residues in human immunodeficiency virus type 1 IN required for efficient proviral DNA formation at steps prior to integration in dividing and nondividing cells.Semantic proximity Read ↗

Evaluation of the Functional Involvement of Human Immunodeficiency Virus Type 1 Integrase in Nuclear Import of Viral cDNA during Acute InfectionSemantic proximity Read ↗

The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA.Semantic proximity Read ↗

Identification of critical motifs within HIV-1 integrase required for importin α3 interaction and viral cDNA nuclear import.Semantic proximity Read ↗

The Cell Cycle Independence of HIV Infections Is Not Determined by Known Karyophilic Viral ElementsSemantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription ComplexSemantic proximity Read ↗

Insight into the ERVK Integrase – Propensity for DNA DamageSemantic proximity Read ↗

Mutations in the catalytic core or the C-terminus of murine leukemia virus (MLV) integrase disrupt virion infectivity and exert diverse effects on reverse transcription.Semantic proximity Read ↗

Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cellsSemantic proximity Read ↗

Importin α3 Interacts with HIV-1 Integrase and Contributes to HIV-1 Nuclear Import and ReplicationSemantic proximity Read ↗

Minimal core domain of HIV-1 integrase for biological activity.Semantic proximity Read ↗

Reversion of the lethal phenotype of an HIV-1 integrase mutant virus by overexpression of the same integrase mutant protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.