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Article

Identification of critical motifs within HIV-1 integrase required for importin α3 interaction and viral cDNA nuclear import.

Journal of molecular biology - 29 Jul 2011

Jayappa Kallesh Danappa, Ao Zhujun, Yang Ming, Wang Junzhi, Yao Xiaojian

Abstract excerpt

The viral cDNA nuclear import is an important requirement for human immunodeficiency virus type 1 (HIV-1) replication in dividing and nondividing cells. Our recent study identified a specific interaction of importin α3 (Impα3) with HIV-1 integrase (IN) and its involvement in viral cDNA nuclear import. In this study, we have performed a more detailed investigation on the molecular mechanism of how HIV-1 IN...

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PMID: 21763491
DOI: 10.1016/j.jmb.2011.04.011

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Identification of critical motifs within HIV-1 integrase required for importin α3 interaction and viral cDNA nuclear import.PMID 21763491Read ↗

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