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Article

The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA.

Journal of virology - 1 Aug 2000

Petit C, Schwartz O, Mammano F

Abstract excerpt

Integrase (IN) is a key component of the preintegration nucleoprotein complex (PIC), which transports the retroviral genome from the cytoplasm to the nucleus of newly infected cells. Retroviral IN proteins have intrinsic karyophilic properties, which for human immunodeficiency virus type 1 (HIV-1) are currently attributed to regions that display sequence homology to previously characterized nuclear localization...

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Identifiers

PMID: 10888652
DOI: 10.1128/jvi.74.15.7119-7126.2000
PMCID: PMC112230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA.PMID 10888652Read ↗

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