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Article

Independent origin of plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia.

Emerging infectious diseases - 1 Aug 2014

Alifrangis Michael, Nag Sidsel, Schousboe Mette L, Ishengoma Deus, Lusingu John, Pota Hirva, Kavishe Reginald A, Pearce Richard, Ord Rosalynn, Lynch Caroline, Dejene Seyoum, Cox Jonathan, Rwakimari John, Minja Daniel T R, Lemnge Martha M, Roper Cally

Abstract excerpt

Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine-pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps and the triple-mutant Pfdhfr. Using samples collected during 2004-2008, we investigated the evolutionary origin of the A581G mutation by characterizing...

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Identifiers

PMID: 25061906
DOI: 10.3201/eid2008.131897
PMCID: PMC4111169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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