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Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H.

Malaria journal - 22 Oct 2020

Pacheco M Andreína, Schneider Kristan A, Cheng Qiuying, Munde Elly O, Ndege Caroline, Onyango Clinton, Raballah Evans, Anyona Samuel B, Ouma Collins, Perkins Douglas J, Escalante Ananias A

Abstract excerpt

BACKGROUND: Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and dhps (Pfdhps) genes confer resistance to pyrimethamine and sulfadoxine, respectively. Here, the frequencies of SP resistance-associated mutations from 2005 to 2018 were compared in samples from...

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Antimalarials
Drug Resistance
Infant
Infant, Newborn
Kenya

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmodium falciparum

Protozoan Proteins

Tetrahydrofolate Dehydrogenase

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Identifiers

PMID: 33092587
DOI: 10.1186/s12936-020-03454-8
PMCID: PMC7583259

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