Article
Antifolate resistance in Plasmodium falciparum: multiple origins and identification of novel dhfr alleles.
The Journal of infectious diseases - 15 Jul 2006
McCollum Andrea M, Poe Amanda C, Hamel Mary, Huber Curtis, Zhou Zhiyong, Shi Ya Ping, Ouma Peter, Vulule John, Bloland Peter, Slutsker Laurence, Barnwell John W, Udhayakumar Venkatachalam, Escalante Ananias A
Abstract excerpt
BACKGROUND: Sulfadoxine-pyrimethamine has been widely used as first-line therapy for uncomplicated malaria throughout sub-Saharan Africa. Recent studies conducted in Asia and Africa suggest the triple-mutant dhfr genotype (51I/59R/108N) may have been generated as a single event in Southeast Asia, with subsequent spread of the single lineage to the African continent, but this hypothesis needs further validation....
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