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Article

Increasing prevalence of a novel triple-mutant dihydropteroate synthase genotype in Plasmodium falciparum in western Kenya.

Antimicrobial agents and chemotherapy - 1 Jul 2015

Lucchi Naomi W, Okoth Sheila Akinyi, Komino Franklin, Onyona Philip, Goldman Ira F, Ljolje Dragan, Shi Ya Ping, Barnwell John W, Udhayakumar Venkatachalam, Kariuki Simon

Abstract excerpt

The molecular basis of sulfadoxine-pyrimethamine (SP) resistance lies in a combination of single-nucleotide polymorphisms (SNPs) in two genes coding for Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and P. falciparum dihydropteroate synthase (Pfdhps), targeted by pyrimethamine and sulfadoxine, respectively. The continued use of SP for intermittent preventive treatment in pregnant women in many African...

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Identifiers

PMID: 25896703
DOI: 10.1128/AAC.04961-14
PMCID: PMC4468674

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Increasing prevalence of a novel triple-mutant dihydropteroate synthase genotype in Plasmodium falciparum in western Kenya.PMID 25896703Read ↗

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