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Article

High multiple mutations of Plasmodium falciparum-resistant genotypes to sulphadoxine-pyrimethamine in Lagos, Nigeria.

Infectious diseases of poverty - 11 Jul 2020

Quan Hong, Igbasi Uche, Oyibo Wellington, Omilabu Sunday, Chen Shen-Bo, Shen Hai-Mo, Okolie Chukwuma, Chen Jun-Hu, Zhou Xiao-Nong

Abstract excerpt

BACKGROUND: Plasmodium falciparum-resistance to sulphadoxine-pyrimethamine (SP) has been largely reported among pregnant women. However, the profile of resistance markers to SP dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) in the general population are varied and not frequently monitored. Currently, SP is used as partner drug for artemisinin combination therapy (SP-artesunate) in some...

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PMID: 32653033
DOI: 10.1186/s40249-020-00712-4
PMCID: PMC7353807

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