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Article

Protein-Protein Interactions Mediated by Intrinsically Disordered Protein Regions Are Enriched in Missense Mutations.

Biomolecules - 24 Jul 2020

Wong Eric T C, So Victor, Guron Mike, Kuechler Erich R, Malhis Nawar, Bui Jennifer M, Gsponer Jörg

Abstract excerpt

Because proteins are fundamental to most biological processes, many genetic diseases can be traced back to single nucleotide variants (SNVs) that cause changes in protein sequences. However, not all SNVs that result in amino acid substitutions cause disease as each residue is under different structural and functional constraints. Influential studies have shown that protein-protein interaction interfaces are...

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Identifiers

PMID: 32722039
DOI: 10.3390/biom10081097
PMCID: PMC7463635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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