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Article

Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Jul 2014

Molina-Calavita Maria, Barnat Monia, Elias Salah, Aparicio Esther, Piel Matthieu, Humbert Sandrine

Abstract excerpt

A polyglutamine expansion in huntingtin (HTT) causes the specific death of adult neurons in Huntington's disease (HD). Most studies have thus focused on mutant HTT (mHTT) toxicity in adulthood, and its developmental effects have been largely overlooked. We found that mHTT caused mitotic spindle misorientation in cultured cells by altering the localization of dynein, NuMA, and the p150(Glued) subunit of dynactin...

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Source

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Identifiers

PMID: 25057205
DOI: 10.1523/JNEUROSCI.0715-14.2014
PMCID: PMC6608303

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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