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Article

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells.

PloS one - 1 Jan 2016

Lopes Carla, Aubert Sophie, Bourgois-Rocha Fany, Barnat Monia, Rego Ana Cristina, Déglon Nicole, Perrier Anselme L, Humbert Sandrine

Abstract excerpt

Mutations of the huntingtin protein (HTT) gene underlie both adult-onset and juvenile forms of Huntington's disease (HD). HTT modulates mitotic spindle orientation and cell fate in mouse cortical progenitors from the ventricular zone. Using human embryonic stem cells (hESC) characterized as carrying mutations associated with adult-onset disease during pre-implantation genetic diagnosis, we investigated the...

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Identifiers

PMID: 26863614
DOI: 10.1371/journal.pone.0148680
PMCID: PMC4749329

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells.PMID 26863614Read ↗

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