Article

Tubulin autoregulation mediator TTC5 regulates neuronal morphology and migration

2026-06-24

Abstract excerpt

<h4>Summary</h4> Microtubule dynamics regulation is critical for neuronal development, yet how neurons regulate tubulin levels remains poorly understood. Tetratricopeptide repeat domain 5 (TTC5) mediates the co-translational degradation of tubulin transcripts in response to excess soluble tubulin, a.k.a. “tubulin autoregulation”, and TTC5 mutations are associated with cerebral atrophy, speech and motor impairment...

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Literature Corpus work: 5ee137e7-3cb6-5d16-825c-972ea985b362
DOI: 10.64898/2026.06.23.733857

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