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Article

Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics.

Scientific reports - 12 Jan 2017

Jin Mingyue, Pomp Oz, Shinoda Tomoyasu, Toba Shiori, Torisawa Takayuki, Furuta Ken'ya, Oiwa Kazuhiro, Yasunaga Takuo, Kitagawa Daiju, Matsumura Shigeru, Miyata Takaki, Tan Thong Teck, Reversade Bruno, Hirotsune Shinji

Abstract excerpt

Human mutations in KATNB1 (p80) cause severe congenital cortical malformations, which encompass the clinical features of both microcephaly and lissencephaly. Although p80 plays critical roles during brain development, the underlying mechanisms remain predominately unknown. Here, we demonstrate that p80 regulates microtubule (MT) remodeling in combination with NuMA (nuclear mitotic apparatus protein) and...

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Identifiers

PMID: 28079116
DOI: 10.1038/srep39902
PMCID: PMC5228124

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