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Article

Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function.

Cancer research - 15 May 1999

Kamijo T, van de Kamp E, Chong M J, Zindy F, Diehl J A, Sherr C J, McKinnon P J

Abstract excerpt

The alternative reading frame product (p19ARF) of the mouse INK4a/ARF locus is induced by oncoproteins such as Myc and E1A as part of a checkpoint response that limits cell cycle progression in response to hyperproliferative signals. ARF binds directly to Mdm2 to prevent down-regulation of p53 and thereby promotes p53-dependent transcription and cell cycle arrest. However, ARF is not required for p53 induction in...

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PMID: 10344759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function.PMID 10344759Read ↗

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.Semantic proximity Read ↗

The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.Semantic proximity Read ↗

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.Semantic proximity Read ↗

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2Semantic proximity Read ↗

Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis.Semantic proximity Read ↗

Involvement of the INK4a/Arf gene locus in senescence.Semantic proximity Read ↗

Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice.Semantic proximity Read ↗

Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development.Semantic proximity Read ↗

Dynamics of ARF regulation that control senescence and cancerSemantic proximity Read ↗

Post-Translational Regulation of ARF: Perspective in CancerSemantic proximity Read ↗

The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivoSemantic proximity Read ↗

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.Semantic proximity Read ↗

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