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Article

Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection.

The Journal of biological chemistry - 29 Aug 2014

Frescas David, de Lange Titia

Abstract excerpt

The single-stranded DNA binding proteins in mouse shelterin, POT1a and POT1b, accumulate at telomeres as heterodimers with TPP1, which binds TIN2 and thus links the TPP1/POT1 dimers with TRF1 and TRF2/Rap1. When TPP1 is tethered to TIN2/TRF1/TRF2, POT1a is thought to block replication protein A binding to the single-stranded telomeric DNA and prevent ataxia telangiectasia and Rad3-related kinase activation....

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Share to Cell Line, Transformed
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25056954
DOI: 10.1074/jbc.M114.592592
PMCID: PMC4148849

Genes

TPP1
POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection.PMID 25056954Read ↗

POT1 Association with TRF2 Regulates Telomere LengthSemantic proximity Read ↗

TIN2 Functions with TPP1/POT1 To Stimulate Telomerase ProcessivitySemantic proximity Read ↗

TIN2 functions with TPP1/POT1 to stimulate telomerase processivitySemantic proximity Read ↗

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In VivoSemantic proximity Read ↗

A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrixSemantic proximity Read ↗

Telomere Maintenance through Spatial Control of Telomeric ProteinsSemantic proximity Read ↗

Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivitySemantic proximity Read ↗

Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes.Semantic proximity Read ↗

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.Semantic proximity Read ↗

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POT1 and TRF2 Cooperate To Maintain Telomeric IntegritySemantic proximity Read ↗

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