Article

TIN2 functions with TPP1/POT1 to stimulate telomerase processivity

2018-10-05

Abstract excerpt

Telomere length maintenance is crucial for cells that divide many times. TIN2 is an important regulator of telomere length, and mutations in TINF2 , the gene encoding TIN2, cause short telomere syndromes. While the genetics underscore the importance of TIN2, the mechanism through which TIN2 regulates telomere length remains unclear. Here, we characterize the effects of TIN2 on telomerase activity. We identified a...

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Literature Corpus work: 6a15ae31-e148-595f-88d9-47295b51fb41
DOI: 10.1101/435958

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