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Telomere Maintenance through Spatial Control of Telomeric Proteins

12 Jun 2007

Abstract excerpt

The six human telomeric proteins TRF1, TRF2, RAP1, TIN2, POT1, and TPP1 can form a complex called the telosome/shelterin, which is required for telomere protection and length control. TPP1 has been shown to regulate both POT1 telomere localization and telosome assembly through its binding to TIN2. It remains to be determined where such interactions take place and whether cellular compartmentalization of telomeric...

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Identifiers

PMID: 17562870
DOI: 10.1128/mcb.00603-07

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Telomere Maintenance through Spatial Control of Telomeric ProteinsPMID 17562870Read ↗

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POT1 Association with TRF2 Regulates Telomere LengthSemantic proximity Read ↗

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Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection.Semantic proximity Read ↗

The Protein Network Surrounding the Human Telomere Repeat Binding Factors TRF1, TRF2, and POT1Semantic proximity Read ↗

Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cellsSemantic proximity Read ↗

Regulation of Telomerase by Telomeric ProteinsSemantic proximity Read ↗

POT1-TPP1 telomere length regulation and diseaseSemantic proximity Read ↗

TRF1 and TRF2 form distinct shelterin subcomplexes at telomeresSemantic proximity Read ↗

Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.Semantic proximity Read ↗

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