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Article

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.

The Journal of biological chemistry - 5 Nov 2004

Ye Jeffrey Zheng-Sheng, Donigian Jill R, van Overbeek Megan, Loayza Diego, Luo Yan, Krutchinsky Andrew N, Chait Brian T, de Lange Titia

Abstract excerpt

Human telomeres contain two related telomeric DNA-binding proteins, TRF1 and TRF2. The TRF1 complex contains the TRF1 interacting partner, TIN2, as well as PIP1 and POT1 and regulates telomere-length homeostasis. The TRF2 complex is primarily involved in telomere protection and contains the TRF2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15316005
DOI: 10.1074/jbc.M409047200

Genes

POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15316005-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.PMID 15316005Read ↗

TIN2 Mediates Functions of TRF2 at Human TelomeresSemantic proximity Read ↗

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.Semantic proximity Read ↗

The Protein Network Surrounding the Human Telomere Repeat Binding Factors TRF1, TRF2, and POT1Semantic proximity Read ↗

Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes.Semantic proximity Read ↗

Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosisSemantic proximity Read ↗

A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrixSemantic proximity Read ↗

Telomere Maintenance through Spatial Control of Telomeric ProteinsSemantic proximity Read ↗

POT1 Association with TRF2 Regulates Telomere LengthSemantic proximity Read ↗

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusionsSemantic proximity Read ↗

POT1 and TRF2 Cooperate To Maintain Telomeric IntegritySemantic proximity Read ↗

Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the TelomereSemantic proximity Read ↗

Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere ElongationSemantic proximity Read ↗

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