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Article

A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix

15 Mar 2009

Abstract excerpt

Telomeres are specialized heterochromatin at the ends of linear chromosomes. Telomeres are crucial for maintaining genome stability and play important roles in cellular senescence and tumor biology. Six core proteins-TRF1, TRF2, TIN2, POT1, TPP1 and Rap1 (termed the telosome or shelterin complex)-regulate telomere structure and function. One of these proteins, TIN2, regulates telomere length and structure...

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Share to DNA Repair Mechanisms
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Identifiers

PMID: 19229133
DOI: 10.4161/cc.8.6.7941

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A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrixPMID 19229133Read ↗

TIN2 Functions with TPP1/POT1 To Stimulate Telomerase ProcessivitySemantic proximity Read ↗

TIN2 functions with TPP1/POT1 to stimulate telomerase processivitySemantic proximity Read ↗

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.Semantic proximity Read ↗

Telomere Maintenance through Spatial Control of Telomeric ProteinsSemantic proximity Read ↗

Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes.Semantic proximity Read ↗

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.Semantic proximity Read ↗

The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro.Semantic proximity Read ↗

Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection.Semantic proximity Read ↗

TRF1 and TRF2 form distinct shelterin subcomplexes at telomeresSemantic proximity Read ↗

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In VivoSemantic proximity Read ↗

TIN2 Mediates Functions of TRF2 at Human TelomeresSemantic proximity Read ↗

The Protein Network Surrounding the Human Telomere Repeat Binding Factors TRF1, TRF2, and POT1Semantic proximity Read ↗

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