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Article

Magnified effects of the COMT gene on white-matter microstructure in very old age.

Brain structure & function - 1 Sept 2015

Papenberg Goran, Lövdén Martin, Laukka Erika J, Kalpouzos Grégoria, Keller Lina, Graff Caroline, Köhncke Ylva, Li Tie-Qiang, Fratiglioni Laura, Bäckman Lars

Abstract excerpt

Genetic factors may partly account for between-person differences in brain integrity in old age. Evidence from human and animal studies suggests that the dopaminergic system is implicated in the modulation of white-matter integrity. We investigated whether a genetic variation in the Catechol-O-Methyltransferase (COMT) Val158Met polymorphism, which influences dopamine availability in prefrontal cortex, contributes...

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Source

Identifiers

PMID: 25056932
DOI: 10.1007/s00429-014-0835-4

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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