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Article

Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Sept 2006

Usuki Fusako, Yamashita Akio, Kashima Isao, Higuchi Itsuro, Osame Mitsuhiro, Ohno Shigeo

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is an mRNA quality-control mechanism that degrades aberrant mRNAs containing premature translation termination codons (PTCs). The essential proteins for NMD include SMG-1, a protein kinase, and Upf1, a substrate of SMG-1 with RNA helicase activity. In this study...

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Source

Identifiers

PMID: 16807116
DOI: 10.1016/j.ymthe.2006.04.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16807116-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts.PMID 16807116Read ↗

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