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Article

Protein kinases that phosphorylate activated G protein-coupled receptors.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 1995

Premont R T, Inglese J, Lefkowitz R J

Abstract excerpt

G protein-coupled receptor kinases (GRKs) are a family of serine/threonine protein kinases that specifically recognize agonist-occupied, activated G protein-coupled receptor proteins as substrates. Phosphorylation of an activated receptor by a GRK terminates signaling by that receptor, by initiating the uncoupling of the receptor from heterotrimeric G proteins. Six distinct mammalian GRKs are known, which differ...

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Source

Identifiers

PMID: 7781920
DOI: 10.1096/fasebj.9.2.7781920

Genes

GRK1
GRK2
GRK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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