Article
Protein kinases that phosphorylate activated G protein-coupled receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 1995
Premont R T, Inglese J, Lefkowitz R J
Abstract excerpt
G protein-coupled receptor kinases (GRKs) are a family of serine/threonine protein kinases that specifically recognize agonist-occupied, activated G protein-coupled receptor proteins as substrates. Phosphorylation of an activated receptor by a GRK terminates signaling by that receptor, by initiating the uncoupling of the receptor from heterotrimeric G proteins. Six distinct mammalian GRKs are known, which differ...
Topics
- Amino Acid Sequence
- Animals
- Cell Membrane
- Eye Proteins
- G-Protein-Coupled Receptor Kinase 1
- GTP-Binding Proteins
- Mammals
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Kinases