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Article

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner.

Cell death and differentiation - 1 Feb 2017

Pinto Milena, Pickrell Alicia M, Wang Xiao, Bacman Sandra R, Yu Aixin, Hida Aline, Dillon Lloye M, Morton Paul D, Malek Thomas R, Williams Siôn L, Moraes Carlos T

Abstract excerpt

We observed that the transient induction of mtDNA double strand breaks (DSBs) in cultured cells led to activation of cell cycle arrest proteins (p21/p53 pathway) and decreased cell growth, mediated through reactive oxygen species (ROS). To investigate this process in vivo we developed a mouse model where we could transiently induce mtDNA DSBs ubiquitously. This transient mtDNA damage in mice caused an accelerated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27911443
DOI: 10.1038/cdd.2016.123
PMCID: PMC5299712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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