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Article

The innate immune system in host mice targets cells with allogenic mitochondrial DNA.

The Journal of experimental medicine - 25 Oct 2010

Ishikawa Kaori, Toyama-Sorimachi Noriko, Nakada Kazuto, Morimoto Mami, Imanishi Hirotake, Yoshizaki Mariko, Sasawatari Shigemi, Niikura Mamoru, Takenaga Keizo, Yonekawa Hiromichi, Hayashi Jun-Ichi

Abstract excerpt

Mitochondrial DNA (mtDNA) has been proposed to be involved in respiratory function, and mtDNA mutations have been associated with aging, tumors, and various disorders, but the effects of mtDNA imported into transplants from different individuals or aged subjects have been unclear. We examined this issue by generating trans-mitochondrial tumor cells and embryonic stem cells that shared the syngenic C57BL/6 (B6)...

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Identifiers

PMID: 20937705
DOI: 10.1084/jem.20092296
PMCID: PMC2964578

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