Article
Thioredoxin overexpression in mice, model of attenuation of oxidative stress, prevents benzene-induced hemato-lymphoid toxicity and thymic lymphoma.
Experimental hematology - 1 Dec 2006
Li Guang-Xun, Hirabayashi Yoko, Yoon Byung-Il, Kawasaki Yasushi, Tsuboi Isao, Kodama Yukio, Kurokawa Yuji, Yodoi Junji, Kanno Jun, Inoue Tohru
Abstract excerpt
OBJECTIVE: Reactive oxygen species (ROS), generated following benzene exposure, are considered to trigger the development of hematopoietic neoplasms, although little supporting evidence has been found. In this study, we examined whether the experimental elimination of ROS generated following benzene exposure prevents the development of benzene-induced hematopoietic disorders to clarify the mechanism underlying...
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