Thioredoxin overexpression in mice, model of attenuation of oxidative stress, prevents benzene-induced hemato-lymphoid toxicity and thymic lymphoma.

doi:10.1016/j.exphem.2006.08.005

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Article

Thioredoxin overexpression in mice, model of attenuation of oxidative stress, prevents benzene-induced hemato-lymphoid toxicity and thymic lymphoma.

Experimental hematology - 1 Dec 2006

Li Guang-Xun, Hirabayashi Yoko, Yoon Byung-Il, Kawasaki Yasushi, Tsuboi Isao, Kodama Yukio, Kurokawa Yuji, Yodoi Junji, Kanno Jun, Inoue Tohru

Abstract excerpt

OBJECTIVE: Reactive oxygen species (ROS), generated following benzene exposure, are considered to trigger the development of hematopoietic neoplasms, although little supporting evidence has been found. In this study, we examined whether the experimental elimination of ROS generated following benzene exposure prevents the development of benzene-induced hematopoietic disorders to clarify the mechanism underlying...

Topics

Animals
Benzene
Burkitt Lymphoma
Carcinogens
Cyclin-Dependent Kinase Inhibitor p21
Cytochrome P-450 CYP2E1
Down-Regulation
Genotype
Hematologic Diseases
Humans
Immunity, Innate
Mice
Mice, Inbred C57BL

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Models, Animal

Oxidative Stress

RNA, Messenger

Reactive Oxygen Species

Source

Open in PubMed

Identifiers

PMID: 17157166
DOI: 10.1016/j.exphem.2006.08.005

Provenance

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