Article
Mechanisms that clear mutations drive field cancerization in mammary tissue.
Nature - 1 Sept 2024
Ciwinska Marta, Messal Hendrik A, Hristova Hristina R, Lutz Catrin, Bornes Laura, Chalkiadakis Theofilos, Harkes Rolf, Langedijk Nathalia S M, Hutten Stefan J, Menezes Renée X, Jonkers Jos, Prekovic Stefan, Simons Benjamin D, Scheele Colinda L G J, van Rheenen Jacco
Abstract excerpt
Oncogenic mutations are abundant in the tissues of healthy individuals, but rarely form tumours1-3. Yet, the underlying protection mechanisms are largely unknown. To resolve these mechanisms in mouse mammary tissue, we use lineage tracing to map the fate of wild-type and Brca1-/-;Trp53-/- cells, and find that both follow a similar pattern of loss and spread within ducts. Clonal analysis reveals that ducts consist...
Topics
Join the communities discussing this publication.