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Article

Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA.

Nature - 14 Aug 2014

Hwang William L, Deindl Sebastian, Harada Bryan T, Zhuang Xiaowei

Abstract excerpt

Imitation switch (ISWI)-family remodelling enzymes regulate access to genomic DNA by mobilizing nucleosomes. These ATP-dependent chromatin remodellers promote heterochromatin formation and transcriptional silencing by generating regularly spaced nucleosome arrays. The nucleosome-spacing activity arises from the dependence of nucleosome translocation on the length of extranucleosomal linker DNA, but the underlying...

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Identifiers

PMID: 25043036
DOI: 10.1038/nature13380
PMCID: PMC4134374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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