Emerging roles of linker histones in regulating chromatin structure and function.

doi:10.1038/nrm.2017.94

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Article

Emerging roles of linker histones in regulating chromatin structure and function.

Nature reviews. Molecular cell biology - 1 Mar 2018

Fyodorov Dmitry V, Zhou Bing-Rui, Skoultchi Arthur I, Bai Yawen

Abstract excerpt

Together with core histones, which make up the nucleosome, the linker histone (H1) is one of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to the nucleosome to form the next structural unit of metazoan chromatin, the chromatosome, which may help chromatin to fold into higher-order structures. Despite their important roles in regulating the structure and function of...

Topics

Amino Acid Sequence
Animals
Chromatin
Chromatin Assembly and Disassembly
DNA
DNA Repair
DNA Replication
Epigenesis, Genetic
Genetic Variation
Genomic Instability
Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Models, Biological

Models, Molecular

Nucleic Acid Conformation

Nucleosomes

Protein Conformation

Sequence Homology, Amino Acid

Source

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Identifiers

PMID: 29018282
DOI: 10.1038/nrm.2017.94
PMCID: PMC5897046

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