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Article

A nucleotide-driven switch regulates flanking DNA length sensing by a dimeric chromatin remodeler.

Molecular cell - 5 Mar 2015

Leonard John D, Narlikar Geeta J

Abstract excerpt

The ATP-dependent chromatin assembly factor (ACF) spaces nucleosomes to promote formation of silent chromatin. Two copies of its ATPase subunit SNF2h bind opposite sides of a nucleosome, but how these protomers avoid competition is unknown. SNF2h senses the length of DNA flanking a nucleosome via its HAND-SANT-SLIDE (HSS) domain, yet it is unclear how this interaction enhances remodeling. Using covalently...

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Share to Adenosine Diphosphate
Share to Chromatin Assembly and Disassembly
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25684208
DOI: 10.1016/j.molcel.2015.01.008
PMCID: PMC4355161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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