Article

Impact of histone N-terminal domains and linker DNA on H2A.Z deposition by yeast SWR1C

2026-05-02

Abstract excerpt

ATP-dependent chromatin remodeling enzymes play a central role in governing the essential functions of the genome, and deficiencies in their catalytic function often lead to developmental disorders or disease. While most remodelers use the energy of ATP hydrolysis to either mobilize nucleosomes or evict histone octamers, yeast SWR1C catalyzes the ATP-dependent replacement of nucleosomal H2A/H2B dimers with variant...

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Literature Corpus work: 7605b633-c3b6-55f6-90d6-138bdc9f24b0
DOI: 10.64898/2026.05.01.722189

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