Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer mutations rewire linker histone interaction network and compromise chromatosome stability.

Biophysical journal - 17 Mar 2026

Liu Gege, Xu Wang, Hu Guanhua, Zhang Houfang, Peng Yunhui

Abstract excerpt

Histone H1 is essential for higher-order chromatin organization, stabilizing linker DNA and bridging adjacent nucleosomes. To elucidate how cancer-associated mutations perturb this architectural hub, we constructed a comprehensive H1-centered interaction network by integrating structural and cross-linking mass spectrometry data, encompassing interactions among histones, DNA, and regulatory partners. Mapping...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to Histones
Share to Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to Nucleosomes

Share to Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 41620823
DOI: 10.1016/j.bpj.2026.01.050
PMCID: PMC13351677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer mutations rewire linker histone interaction network and compromise chromatosome stability.PMID 41620823Read ↗

Deciphering principles of nucleosome interactions and impact of cancer-associated mutations from comprehensive interaction network analysis.Semantic proximity Read ↗

Histone H1 alterations in cancer.Semantic proximity Read ↗

Emerging roles of linker histones in regulating chromatin structure and function.Semantic proximity Read ↗

Cancer Histone Mutations Impact Binding and DNA Repair Processes, Leading to Increased MutagenesisSemantic proximity Read ↗

Oncohistone mutations enhance chromatin remodeling and alter cell fates.Semantic proximity Read ↗

The dynamics of histone H1 function in chromatin.Semantic proximity Read ↗

The missing linker: emerging trends for H1 variant-specific functions.Semantic proximity Read ↗

Post-Translation Modifications and Mutations of Human Linker Histone Subtypes: Their Manifestation in Disease.Semantic proximity Read ↗

Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo.Semantic proximity Read ↗

CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor toleranceSemantic proximity Read ↗

Acidic patch histone mutations and their effects on nucleosome remodeling.Semantic proximity Read ↗

Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.