Article
The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding.
The EMBO journal - 16 Dec 2002
Bonaldi Tiziana, Längst Gernot, Strohner Ralf, Becker Peter B, Bianchi Marco E
Abstract excerpt
Nucleosome remodelling complexes CHRAC and ACF contribute to chromatin dynamics by converting chemical energy into sliding of histone octamers on DNA. Their shared ATPase subunit ISWI binds DNA at the sites of entry into the nucleosome. A prevalent model assumes that DNA distortions catalysed by ISWI are converted into relocation of DNA relative to a histone octamer. HMGB1, one of the most abundant nuclear...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
