Article
Regulation of DNA Translocation Efficiency within the Chromatin Remodeler RSC/Sth1 Potentiates Nucleosome Sliding and Ejection.
Molecular cell - 5 May 2016
Clapier Cedric R, Kasten Margaret M, Parnell Timothy J, Viswanathan Ramya, Szerlong Heather, Sirinakis George, Zhang Yongli, Cairns Bradley R
Abstract excerpt
The RSC chromatin remodeler slides and ejects nucleosomes, utilizing a catalytic subunit (Sth1) with DNA translocation activity, which can pump DNA around the nucleosome. A central question is whether and how DNA translocation is regulated to achieve sliding versus ejection. Here, we report the regulation of DNA translocation efficiency by two domains residing on Sth1 (Post-HSA and Protrusion 1) and by...
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