Article
Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2016
Ziauddeen Hisham, Nestor Liam J, Subramaniam Naresh, Dodds Chris, Nathan Pradeep J, Miller Sam R, Sarai Bhopinder K, Maltby Kay, Fernando Disala, Warren Liling, Hosking Louise K, Waterworth Dawn, Korzeniowska Anna, Win Beta, Richards Duncan B, Vasist Johnson Lakshmi, Fletcher Paul C, Bullmore Edward T
Abstract excerpt
The A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene, OPRM1, has been much studied in relation to alcohol use disorders. The reported effects of allelic variation at this SNP on alcohol-related behaviors, and on opioid receptor antagonist treatments, have been inconsistent. We investigated the pharmacogenetic interaction between A118G variation and the effects of two μ-opioid...
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