Article
Voluntary intravenous self-administration of alcohol detects an interaction between GABAergic manipulation and GABRG1 polymorphism genotype: a pilot study.
Alcoholism, clinical and experimental research - 1 Jan 2013
Plawecki Martin H, Wetherill Leah, Vitvitskiy Victor, Kosobud Ann, Zimmermann Ulrich S, Edenberg Howard J, O'Connor Sean
Abstract excerpt
BACKGROUND: Operant responding paradigms quantify a subject's motivation for reward, but such studies employing ingested alcohol cannot assure the same incremental increase in brain exposure to alcohol across subjects because of substantial variability in absorption kinetics. We developed a human progressive ratio (PR) paradigm using the computer-assisted self-infusion of ethanol (CASE) system that overcomes such...
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