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Article

A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans.

Alcoholism, clinical and experimental research - 1 Dec 2004

Ray Lara A, Hutchison Kent E

Abstract excerpt

BACKGROUND: Recent research has implicated the endogenous opioid system in the development of alcohol use disorders. The A118G polymorphism of the OPRM1 gene has been shown to confer functional differences to mu-opioid receptors, such that the G variant binds beta-endorphin three times more strongly than the A variant. The goal of this study was to test whether the A118G polymorphism is associated with...

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Source

Identifiers

PMID: 15608594
DOI: 10.1097/01.alc.0000148114.34000.b9

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans.PMID 15608594Read ↗

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The OPRM1 A118G polymorphism: converging evidence against associations with alcohol sensitivity and consumption.Semantic proximity Read ↗

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The μ-opioid receptor and treatment response to naltrexone.Semantic proximity Read ↗

Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden.Semantic proximity Read ↗

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