Article
DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients with Plasmodium vivax malaria.
Malaria journal - 19 Jul 2014
Mendonça Vitor R R, Souza Ligia C L, Garcia Gabriela C, Magalhães Belisa M L, Lacerda Marcus V G, Andrade Bruno B, Gonçalves Marilda S, Barral-Netto Manoel
Abstract excerpt
BACKGROUND: DDX39B (BAT1) encodes an RNA helicase known to regulate expression of TNF and IL-6. Elevated levels of these two cytokines are associated with increased severity of clinical malaria. The aim of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) in the DDX39B, TNF and IL6 genes and the clinical outcomes of patients with Plasmodium vivax malaria. METHODS:...
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