Article
Association of Single-Nucleotide Polymorphisms in IL28B, but Not TNF-α, With Severity of Disease Caused by Andes Virus.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Dec 2015
Angulo Jenniffer, Pino Karla, Echeverría-Chagas Natalia, Marco Claudia, Martínez-Valdebenito Constanza, Galeno Héctor, Villagra Eliecer, Vera Lilian, Lagos Natalia, Becerra Natalia, Mora Judith, Bermúdez Andrea, Cárcamo Marcela, Díaz Janepsy, Miquel Juan Francisco, Ferrés Marcela, López-Lastra Marcelo
Abstract excerpt
BACKGROUND: Andes virus (ANDV) is the sole etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in Chile, with a fatality rate of about 35%. Individual host factors affecting ANDV infection outcome are poorly understood. In this case-control genetic association analysis, we explored the link between single-nucleotide polymorphisms (SNPs) rs12979860, rs8099917 and rs1800629 and the clinical outcome of...
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