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Article

FANCM-associated proteins MHF1 and MHF2, but not the other Fanconi anemia factors, limit meiotic crossovers.

Nucleic acids research - 1 Aug 2014

Girard Chloe, Crismani Wayne, Froger Nicole, Mazel Julien, Lemhemdi Afef, Horlow Christine, Mercier Raphael

Abstract excerpt

Genetic recombination is important for generating diversity and to ensure faithful segregation of chromosomes at meiosis. However, few crossovers (COs) are formed per meiosis despite an excess of DNA double-strand break precursors. This reflects the existence of active mechanisms that limit CO formation. We previously showed that AtFANCM is a meiotic anti-CO factor. The same genetic screen now identified AtMHF2...

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Identifiers

PMID: 25038251
DOI: 10.1093/nar/gku614
PMCID: PMC4132730

Genes

FANCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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