Article
Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM.
Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2015
Séguéla-Arnaud Mathilde, Crismani Wayne, Larchevêque Cécile, Mazel Julien, Froger Nicole, Choinard Sandrine, Lemhemdi Afef, Macaisne Nicolas, Van Leene Jelle, Gevaert Kris, De Jaeger Geert, Chelysheva Liudmilla, Mercier Raphael
Abstract excerpt
Meiotic crossovers (COs) have two important roles, shuffling genetic information and ensuring proper chromosome segregation. Despite their importance and a large excess of precursors (i.e., DNA double-strand breaks, DSBs), the number of COs is tightly regulated, typically one to three per chromosome pair. The mechanisms ensuring that most DSBs are repaired as non-COs and the evolutionary forces imposing this...
Topics
- Arabidopsis
- Arabidopsis Proteins
- Crossing Over, Genetic
- DNA Breaks, Double-Stranded
- DNA Helicases
- DNA Topoisomerases, Type I
- Meiosis
- Mutation
- Phylogeny
- Plants, Genetically Modified
- Recombination, Genetic