Article
FANCM limits meiotic crossovers.
Science (New York, N.Y.) - 22 Jun 2012
Crismani Wayne, Girard Chloé, Froger Nicole, Pradillo Mónica, Santos Juan Luis, Chelysheva Liudmila, Copenhaver Gregory P, Horlow Christine, Mercier Raphaël
Abstract excerpt
The number of meiotic crossovers (COs) is tightly regulated within a narrow range, despite a large excess of molecular precursors. The factors that limit COs remain largely unknown. Here, using a genetic screen in Arabidopsis thaliana, we identified the highly conserved FANCM helicase, which is required for genome stability in humans and yeasts, as a major factor limiting meiotic CO formation. The fancm mutant...
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