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Article

RMI1 and TOP3α limit meiotic CO formation through their C-terminal domains.

Nucleic acids research - 28 Feb 2017

Séguéla-Arnaud Mathilde, Choinard Sandrine, Larchevêque Cécile, Girard Chloé, Froger Nicole, Crismani Wayne, Mercier Raphael

Abstract excerpt

At meiosis, hundreds of programmed DNA double-strand breaks (DSBs) form and are repaired by homologous recombination. From this large number of DSBs, only a subset yields crossovers (COs), with a minimum of one CO per chromosome pair. All DSBs must be repaired and every recombination intermediate must be resolved to avoid subsequent entanglement and chromosome breakage. The conserved BLM-TOP3α-RMI1 (BTR) complex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27965412
DOI: 10.1093/nar/gkw1210
PMCID: PMC5389728

Genes

RMI1
BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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