Article
AAA-ATPase FIDGETIN-LIKE 1 and Helicase FANCM Antagonize Meiotic Crossovers by Distinct Mechanisms.
PLoS genetics - 1 Jul 2015
Girard Chloe, Chelysheva Liudmila, Choinard Sandrine, Froger Nicole, Macaisne Nicolas, Lemhemdi Afef, Lehmemdi Afef, Mazel Julien, Crismani Wayne, Mercier Raphael
Abstract excerpt
Meiotic crossovers (COs) generate genetic diversity and are critical for the correct completion of meiosis in most species. Their occurrence is tightly constrained but the mechanisms underlying this limitation remain poorly understood. Here we identified the conserved AAA-ATPase FIDGETIN-LIKE-1 (FIGL1) as a negative regulator of meiotic CO formation. We show that Arabidopsis FIGL1 limits CO formation genome-wide,...
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