Article
[Association between methylene-tetrahydrofolate reductase gene polymorphisms and chronic myeloid leukemia].
Bulletin du cancer - 1 Sept 2014
Dorgham Samia, Aberkane Meriem, Boughrara Wefa, Antar Soltan Badra, Mehalhal Nemra, Touhami Hadj, Sidimansour Noureddine, Merad Boudia Nadia, Louhibi Lotfi, Boudjema Abdallah
Abstract excerpt
Methylene-tetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolism. Few studies were reported about its relationship with chronic myeloid leukemia (CML). We conducted a case-control study analyzing the prevalence of the polymorphisms MTHFR C677T and MTHFR A1298C in Algerians CML patients. Using TaqMan(®) allelic discrimination assay, we investigate MTHFR C677T and A1298C polymorphism distribution...
Topics
- Alleles
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Genotyping Techniques
- Haplotypes
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Odds Ratio