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Article

Association between the MTHFR A1298C polymorphism and increased risk of acute myeloid leukemia in Brazilian children.

Leukemia & lymphoma - 1 Oct 2006

da Costa Ramos Flavio Jose, Cartaxo Muniz Maria Tereza, Silva Vanessa Cavalcante, Araújo Marcela, Leite Ednalva Pereira, Freitas Elizabete Malaquias, Zanrosso Crisiane Wais, Hatagima Ana, de Mello Maricilda Palandi, Yunes Jose Andrés, Marques-Salles Terezinha de Jesus, Santos Neide, Brandalise Silvia R, Pombo-De-Oliveira Maria S

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the metabolism of folate. The presence of polymorphisms that reduce the activity of MTHFR has been linked to the multifactor process of development of acute leukemia. A case control study was conducted on Brazilian children in different regions of the country with the aim of investigating the role of MTHFR C677T and A1298C polymorphisms as risk...

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Identifiers

PMID: 17071478
DOI: 10.1080/10428190600800132

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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