Article
Association between methylenetetrahydrofolate reductase polymorphism C677T and risk of chronic myeloid leukemia in Serbian population.
Leukemia & lymphoma - 1 Jul 2012
Jakovljevic Ksenija, Malisic Emina, Cavic Milena, Radulovic Sinisa, Jankovic Radmila
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the intracellular folate metabolism which plays an important role in carcinogenesis through DNA methylation and nucleotide synthesis. The common MTHFR single nucleotide polymorphism C677T has been reported to be associated wit...
Topics
- Adult
- Aged
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single Nucleotide
- Risk Factors
- Serbia
- Young Adult