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Article

Methylenetetrahydrofolate reductase gene polymorphisms contribute to acute myeloid leukemia and chronic myeloid leukemia susceptibilities: evidence from meta-analyses.

Cancer epidemiology - 1 Oct 2014

He Hairong, He Gonghao, Wang Taotao, Cai Jiangxia, Wang Yan, Zheng Xiaowei, Dong Yalin, Lu Jun

Abstract excerpt

PURPOSE: The expression of methylenetetrahydrofolate reductase (MTHFR) is associated with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). Most studies have linked the common functional C677T and A1298C polymorphisms of the MTHFR gene and susceptibility to AML and CML, but the results were not consistent. The aim of the present study was to derive a more precise estimation of the relationship....

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Share to MTHFR gene
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Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Leukemia, Myeloid, Acute

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 25080853
DOI: 10.1016/j.canep.2014.07.002

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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