Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in chronic myeloid leukemia: an Egyptian study.

doi:10.1007/s12032-013-0794-2

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Article

Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in chronic myeloid leukemia: an Egyptian study.

Medical oncology (Northwood, London, England) - 1 Jan 2014

Khorshied Mervat Mamdooh, Shaheen Iman Abdel Mohsen, Abu Khalil Reham E, Sheir Rania Elsayed

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) gene plays a pivotal role in folate metabolism. Several genetic variations in MTHFR gene as MTHFR-C677T and MTHFR-A1298C result in decreased MTHFR activity, which could influence efficient DNA methylation and explain susceptibility to different cancers. The etiology of chronic myeloid leukemia (CML) is obscure and little is known about individual's susceptibility to...

Topics

Adult
Alleles
Case-Control Studies
DNA Methylation
Egypt
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Haplotypes
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Male

Methylenetetrahydrofolate Reductase (NADPH2)

Middle Aged

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 24338216
DOI: 10.1007/s12032-013-0794-2

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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