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Article

BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.

Development (Cambridge, England) - 1 Dec 2006

Yoon Byeong S, Pogue Robert, Ovchinnikov Dmitri A, Yoshii Isaac, Mishina Yuji, Behringer Richard R, Lyons Karen M

Abstract excerpt

Bone morphogenetic protein (BMP) signaling pathways are essential regulators of chondrogenesis. However, the roles of these pathways in vivo are not well understood. Limb-culture studies have provided a number of essential insights, including the demonstration that BMP pathways are required for chondrocyte proliferation and differentiation. However, limb-culture studies have yielded contradictory results; some...

Topics

Animals
Apoptosis
Bone Morphogenetic Protein Receptors, Type I
Bone Morphogenetic Proteins
Cell Proliferation
Chondrogenesis
Female
Fibroblast Growth Factors
Growth Plate
Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intracellular Signaling Peptides and Proteins

Male

Mice

Mice, Knockout

Mice, Mutant Strains

Mutation

Osteochondrodysplasias

Phenotype

Source

Identifiers

PMID: 17065231
DOI: 10.1242/dev.02680

Genes

FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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